
Wrenwood Streets is the second chapter or section of the story in Resident Evil Requiem, and it will begin automatically after the events at the Wrenwood Hotel. As usual, throughout this walkthrough we will explain how to progress while completing as much of the game's content as possible, avoiding spoilers whenever possible while ensuring that you obtain all the collectibles, receive help with puzzles and much more.
As soon as the chapter begins, the document log will contain the Victor Gideon Report, which you can take a look at. You also have several weapons at your disposal, but do not start shooting in the middle of the street, as that would hardly be normal.
Continue along the sidewalk in the only possible direction until a cutscene begins. Now there is a perfectly good reason to start shooting, for obvious reasons. Neutralize the threat, move forward and follow the road west. Remember that a shot to the head or leg allows you to approach and use a melee attack, conserving both ammunition and your axe's durability. Keep an eye out for ammo packs that enemies may drop as you head north at the intersection.
If you try to stay off the road, be careful. Some of the bodies lying on the ground are not quite dead. You should have little trouble moving forward while eliminating every enemy. When you encounter the man wielding an iron pipe, defeat him and approach his weapon. You can automatically throw it at the nearest enemy to unlock the Can I Borrow That? achievement/trophy. You can also find items along the roadside, so watch for crates and open vehicles.
Shortly after continuing along the road, you will come across an accident, receive a prompt telling you that you can draw the Requiem and encounter three enemies: do not shoot. Instead, slowly move backwards while keeping all three in sight. If you can line them up and fire the Requiem, you will kill all three with a single shot and unlock the Cost-Effective Carnage achievement/trophy.
Afterwards, continue north through the intersection, eliminating more infected enemies until another cutscene begins. Once it ends, you will be in the Patient Center.