| Logro | Descripción |
|---|
| Amon-Ra | Find the lost artifact of Amon-Ra. |
| Slick Stinger | Defeat Slick Stinger. |
| Kill 'Em All | Kill all enemies on a level of the Bogus Campaign. |
| Turtle Soup | Kill all turtles on Path of Feast/Fear. |
| Fattie Swallower | Defeat Fattie Swallower. |
| Tetrachoke | Defeat Tetrachoke. |
| Robots: A Tale of Two Robots | Defeat Prime-209 & Tech-X. |
| Serious Sam | Complete the Bogus Campaign on Normal difficulty or higher. |
| Are you Serious? | Complete the Bogus Campaign on Serious difficulty. |
| Regular Sam | Complete the Bogus Campaign without buying any upgrades on Normal difficulty or higher. |
| Hardcore | Complete the Bogus Campaign in Hardcore mode on Normal difficulty or higher. |
| Tag Team | Complete the Bogus Campaign in Multiplayer with at least on other player. |
| Gunslinger | Complete the Bogus Campaign in Single Player using only the pistols on Normal difficulty or higher. |
| Seriously Fast | Complete the Bogus Campaign in Single Player within 60 minutes on Normal difficulty or higher. |
| Secret Document | Find both parts of the secret document. |
| Eye of Dr. Platt. | Take the eye from Dr. Platt. |
| Lightersaber | Find the Lightersaber. |
| All Weapons | Find all weapons in the Bogus Campaign. |
| All Stars | Find all stars in the Bogus Campaign. |
| All Extra Lives | Find all extra lives in the Bogus Campaign. |
| All Secrets | Find all secrets in the Bogus Campaign. |
| Auto Shotgun | Find the Auto Shotgun. |
| Duke Nukem | |
| Mr. Buttersworth | |
| Portal | |
| Combat Specialist | Unlock everything in the Combat upgrade tree. |
| Survival Specialist | Unlock everything in the Survival upgrade tree. |
| Weaponry Specialist | Unlock everything in the Weaponry upgrade tree. |
| Savior | Make sure no civilians are killed in the Bogus Campaign. |
| Swordfish | Hack the 4 terminals on Interplanetary Ballistic without failing once. |
| Swift Death | Die within 5 seconds of the start of a level. |
| Disrupt Communications | Disable the satellite on Serious Sabotage. |
| Mine Sweeper | Destroy all mines in the Bogus Campaign. |
| You win, Perfect! | Complete a level of the Bogus Campaign without taking a single point of damage. |
| Survivor | Complete any Survival level on Normal difficulty or higher. |
| Serious Survivor | Complete any Survival level on Serious difficulty. |
| Not another cow level | |
